The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 24, 2021
Filed:
Sep. 06, 2018
Applicant:
Washington University, St. Louis, MO (US);
Inventors:
Vijay Sharma, St. Louis, MO (US);
Jothilingam Sivapackiam, St. Louis, MO (US);
Sundaram S. M. Guruswami, St. Louis, MO (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/04 (2006.01); A61P 25/28 (2006.01); C07D 277/66 (2006.01); C07D 215/22 (2006.01); A61K 31/375 (2006.01); C07D 215/38 (2006.01); C07D 277/64 (2006.01); A61K 31/343 (2006.01); A61K 45/06 (2006.01); A61K 31/436 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0453 (2013.01); A61K 51/0455 (2013.01); A61P 25/28 (2018.01); C07D 215/22 (2013.01); C07D 215/38 (2013.01); C07D 277/64 (2013.01); C07D 277/66 (2013.01); A61K 31/343 (2013.01); A61K 31/375 (2013.01); A61K 31/436 (2013.01); A61K 45/06 (2013.01); A61K 2300/00 (2013.01);
Abstract
Provided herein are compounds for the imaging and treatment of TDP43-mediated disorders. The compounds disclosed bind TDP43 aggregates and may be used to diagnose and treat amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).