The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 24, 2021
Filed:
Oct. 10, 2019
Applicant:
Amicus Therapeutics, Inc., Cranbury, NJ (US);
Inventors:
Hung Do, New Hope, PA (US);
Ce Feng Liu, Brooklyn, NY (US);
Assignee:
Amicus Therapeutics, Inc., Philadelphia, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/79 (2006.01); C07H 21/04 (2006.01); A61K 48/00 (2006.01); A61P 43/00 (2006.01); A61K 38/46 (2006.01); A61K 38/47 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); A61K 38/465 (2013.01); A61K 38/47 (2013.01); A61K 48/0033 (2013.01); A61P 43/00 (2018.01); C12N 15/86 (2013.01); C07H 21/04 (2013.01); C12N 15/79 (2013.01); C12N 2750/14143 (2013.01); C12N 2800/00 (2013.01); C12Y 301/02022 (2013.01); C12Y 302/01022 (2013.01);
Abstract
Provided herein are polypeptides comprising one or more non-native cysteine residues that form a disulfide bridge between non-native cysteines within the protein or between non-native cysteines of two monomers of the protein. Such modified human polypeptides are useful in treatment of genetic diseases via enzyme replacement therapy and/or gene therapy.