The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 24, 2021

Filed:

Jul. 30, 2015
Applicant:

Oxford University Innovation Limited, Oxford, GB;

Inventors:

Simon Draper, Oxford, GB;

Matthew Higgins, Oxford, GB;

Katherine Wright, Oxford, GB;

Alexander Douglas, Oxford, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/015 (2006.01); A61K 39/00 (2006.01); A61K 39/02 (2006.01); C07K 16/20 (2006.01); A61K 39/005 (2006.01); C07K 14/445 (2006.01); C12N 7/00 (2006.01); C12N 15/115 (2010.01);
U.S. Cl.
CPC ...
A61K 39/015 (2013.01); A61K 39/005 (2013.01); C07K 14/445 (2013.01); C07K 16/205 (2013.01); C12N 7/00 (2013.01); A61K 2039/5256 (2013.01); A61K 2039/53 (2013.01); C07K 2319/02 (2013.01); C12N 15/115 (2013.01); C12N 2710/10334 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/24033 (2013.01); C12N 2710/24034 (2013.01); Y02A 50/30 (2018.01);
Abstract

There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising fragments of Reticulocyte-binding protein Homologue 5 (PfRH5). In particular, the invention provides fragments of PfRH5 rationally designed on the basis of the PfRH5 crystal structure, wherein said fragments which lack disordered regions, particularly the flexible N-terminal region and/or flexible central linker.


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