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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11096936 B1

PDFFull Text
Date of Patent:
Aug. 24, 2021

Filed:

Sep. 26, 2016

Cocrystals of naloxone and naltrexone

Applicant:

Pain Therapeutics, Inc., Austin, TX (US);

Inventors:

Remi Barbier, Austin, TX (US);

Nadav Friedmann, Georgetown, TX (US);

Vijay Srirambhatla, Scotland, GB;

Stephen Watt, Scotland, GB;

Michael Zamloot, Austin, TX (US);

Assignee:

Cassava Sciences, Inc., Austin, TX (US);

Attorney:

J.A. Lindeman & Co. PLLC

Primary Examiner:

Sean M Basquill

Int. Cl.
CPC ...
A61K 31/485 (2006.01); A61K 9/70 (2006.01); A61K 9/14 (2006.01); A61K 31/495 (2006.01); A61K 31/635 (2006.01); A61K 31/60 (2006.01); A61K 31/465 (2006.01); A61K 9/00 (2006.01); A61K 31/4468 (2006.01); C07C 35/12 (2006.01); C07C 65/05 (2006.01); C07C 65/10 (2006.01); C07D 213/81 (2006.01); C07D 239/54 (2006.01); C07D 489/08 (2006.01);
U.S. Cl.
CPC ...
A61K 31/485 (2013.01); A61K 9/0014 (2013.01); A61K 9/14 (2013.01); A61K 9/7038 (2013.01); A61K 9/7084 (2013.01); A61K 31/4468 (2013.01); A61K 31/465 (2013.01); A61K 31/495 (2013.01); A61K 31/60 (2013.01); A61K 31/635 (2013.01); C07C 35/12 (2013.01); C07C 65/05 (2013.01); C07C 65/10 (2013.01); C07D 213/81 (2013.01); C07D 239/54 (2013.01); C07D 489/08 (2013.01); C07C 2601/14 (2017.05);
Abstract

This invention relates to cocrystals of naloxone and of naltrexone and their use as opioid antagonists. The cocrystals of the invention include naloxone isonicotinamide cocrystal, naloxone hydrochloride piperazine cocrystal, naltrexone menthol cocrystal, naltrexone thymine cocrystal, naltrexone 2,5-dihydroxybenzoic acid cocrystal, naltrexone salicylic acid cocrystal, naltrexone hydrochloride piperazine cocrystal and naltrexone hydrochloride sulfathiazole cocrystal. A drug-in¬ adhesive transdermal patch containing the opioid analgesic fentanyl or an analog thereof and a cocrystal of naloxone or naltrexone is disclosed. Also disclosed is a method of treating pain, such as acute, chronic or intermittent pain, by applying a drug-in-adhesive transdermal patch of the invention to the skin of a patient in need thereof. Also disclosed is an improved transdermal patch for administering fentanyl or an analog thereof, or for administering a mu opioid agonist, the improvement wherein the transdermal patch contains a cocrystal of the invention in an abuse limiting amount. The improved transdermal patch may be a drug-in-adhesive transdermal patch or a reservoir transdermal patch.

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