The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 24, 2021
Filed:
Apr. 06, 2017
Applicant:
University of Oulu, University of Oulu, FI;
Inventors:
Lari Lehtiö, Oulu, FI;
Harikanth Venkannagari, Oulu, FI;
Bernhard Lüscher, Oulu, FI;
Patricia Verheugd, Oulu, FI;
Assignee:
University of Oulu, University of Oulu, FI;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/166 (2006.01); C07D 213/30 (2006.01); C07D 239/88 (2006.01); C07C 235/46 (2006.01); C12Q 1/48 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/166 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07C 235/46 (2013.01); C07D 213/30 (2013.01); C07D 239/88 (2013.01); C12Q 1/48 (2013.01); C07C 2601/02 (2017.05); G01N 2333/91142 (2013.01); G01N 2500/04 (2013.01);
Abstract
It is an aim of the present invention to provide inhibitors of human diphtheria toxin-like ADP-ribosyltransferases, such as ARTD10, for use as a medicine. It is another aim of the invention to provide compounds for use as human mono-ADP-ribosyltransferase (mARTD) inhibitors in vitro. In the present invention, it has been discovered that human ARTD10, which belongs to an enzyme family linked to cancer biology, can be specifically inhibited by the benzamide comprising compounds disclosed in the invention, such as 4,4'-oxydibenzamide.