The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
Dec. 28, 2016
Applicants:
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
David M. Sabatini, Cambridge, MA (US);
Lynne Chantranupong, Jamaica Plain, MA (US);
Robert A. Saxton, Cambridge, MA (US);
Steven P. Gygi, Foxborough, MA (US);
Melanie P. Gygi, Foxborough, MA (US);
Assignee:
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); G01N 33/68 (2006.01); A61K 31/198 (2006.01); A61K 31/223 (2006.01); G01N 33/50 (2006.01); G01N 33/533 (2006.01); G01N 33/543 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6845 (2013.01); A61K 31/198 (2013.01); A61K 31/223 (2013.01); G01N 33/5041 (2013.01); G01N 33/533 (2013.01); G01N 33/54306 (2013.01); G01N 33/6872 (2013.01); A61K 38/00 (2013.01); G01N 2500/02 (2013.01);
Abstract
The invention relates to methods of identifying compounds that modulate mTORC1 activity in a cell by modulating the activity of CASTOR1, as well as to the use of such identified compounds in the modulation of mTORC1 and the treatment of diseases and conditions characterized by aberrant mTORC1 activity.