The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
Dec. 03, 2013
Almac Diagnostics Limited, Craigavon, GB;
Denis Paul Harkin, Dromore, GB;
Fionnuala Patterson, Greenisland, GB;
Claire Trinder, Stratford-upon-Avon, GB;
Eamonn J. O'Brien, Hillsborough, GB;
Caroline Michie, Nr Kirkcaldy, GB;
Charlie Gourley, Dumfermline, GB;
Laura A. Hill, Lisburn, GB;
Katherine E. Keating, Magherafelt, GB;
Jude O'Donnell, Galbally, GB;
Max Bylesjo, Glasglow, GB;
Steve Deharo, Hillsborough, GB;
Vitali Proutski, Oxford, GB;
Richard Kennedy, Belfast, GB;
Timothy Davison, Hillsborough, GB;
Andreas Winter, Gersthofen, DE;
Andrena McCavigan, Lurgan, GB;
Almac Diagnostic Services Limited, Craigavon, GB;
Abstract
Methods and compositions are provided for the identification of a molecular diagnostic test for cancer. The test identifies cancer subtypes that have an up-regulation or a down-regulation in biomarker expression related to angiogenesis and vascular development. The present invention can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any anti-angiogenic agent. This test may be used in different cancer types and with different drugs that directly or indirectly affect angiogenesis or angiogenesis signalling. In addition, the present invention may be used as a prognostic indicator for certain cancer types. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.