The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
Sep. 29, 2016
Nanyang Technological University, Singapore, SG;
James P Tam, Singapore, SG;
Kien Truc Giang Nguyen, Singapore, SG;
Yuan Cao, Singapore, SG;
Chuan Fa Liu, Singapore, SG;
Nanyang Technological University, Singapore, SG;
Abstract
The present invention relates to a method of forming a peptide of Formula (I) (P-Xaa-Xaa-P) by ligating a first peptide of Formula (II) (P-Xaa-X—R, wherein X is O or S) to a second peptide of Formula (III) (Xaa-Xaa-P) by enzymatically cleaving the bond between 'Asx' and 'X' in the first peptide of Formula (II) and ligating the fragment P-Asx of the first peptide to the second peptide of Formula (III), wherein the enzymatic cleavage and ligation reaction is catalyzed by butelase 1 (SEQ ID NO: 1) and the peptide of Formula (I) is a depsipeptide, preferably a thiodepsipeptide. Further encompassed are peptides and dendrimeric peptide assemblies prepared using the presently disclosed method, as well as use of the dendrimeric peptide assemblies as a vaccine, medicament, or diagnostic agent, particularly as an antimicrobial agent.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile