The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
Jul. 25, 2018
Applicant:
Genentech, Inc., South San Francisco, CA (US);
Inventors:
James Giulianotti, Belmont, CA (US);
Dorothea E. Reilly, San Francisco, CA (US);
Kieran Aurori, South San Francisco, CA (US);
Laura C. Simmons, Burlingame, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2006.01); C07K 16/00 (2006.01); C07K 16/22 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01); C12N 15/70 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); C07K 16/00 (2013.01); C07K 16/22 (2013.01); C07K 16/244 (2013.01); C07K 16/247 (2013.01); C07K 16/2809 (2013.01); C12N 15/70 (2013.01); C12P 21/00 (2013.01); C07K 2317/14 (2013.01); C07K 2317/50 (2013.01); C07K 2317/622 (2013.01); C07K 2319/00 (2013.01);
Abstract
Provided herein are methods of producing a recombinant polypeptide containing two chains, such as an immune mobilizing monoclonal T-cell receptor against cancer (ImmTAC) protein including an alpha chain and a beta chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.