The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
Jul. 18, 2018
Tokushima University, Tokushima, JP;
Oncotherapy Science, Inc., Kawasaki, JP;
Toyomasa Katagiri, Tokushima, JP;
Tetsuro Yoshimaru, Tokushima, JP;
Takashi Miyamoto, Kawasaki, JP;
Yasuhide Okamoto, Kawasaki, JP;
TOKUSHIMA UNIVERSITY, Tokushima, JP;
ONCOTHERAPY SCIENCE, INC., Kawasaki, JP;
Abstract
The present invention provides peptides having a structure in which portions of a dominant-negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 are replaced by at least two stapling structures. The peptides of the present invention have excellent cell growth inhibiting activity. The cell growth inhibiting activity lasts longer, compared to a single-stapled peptide. Therefore, the peptides of the present invention have a feature suitable for clinical applications in cancer therapy.