The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
Nov. 29, 2017
Oncotyrol Center for Personalized Cancer Medicine Gmbh, Innsbruck, AT;
Vichem Chemie Kutató Korlátolt Felelösségü Társaság, Budapest, HU;
Winfried Wunderlech, Bovenden, DE;
Lukas A. Huber, Schwaz, AT;
Johann Jakob Leban, Innsbruck-Igls, AT;
János Pató, Budapest, HU;
László Örfi, Budapest, HU;
Wáczek Frigyes, Budapest, HU;
Péter Bánhegyi, Budapest, HU;
Anna Sípos, Dunakeszi, HU;
Csaba Szántai-kis, Budapest, HU;
MEDIZINISCHE UNIVERSITÄT INNSBRUCK, Innsbruck, AT;
Vichem Chemie Kutató Korlátolt Felelösségü Társaság, Budapest, HU;
Abstract
The present invention relates to 3-amino-pyrazolo[3,4-d]pyrimidin-4-ones, such as for example, N-{4-[1-(2,6-dichloro-4-sulfamoyl-phenyl)-3-dimethylamino-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylmethyl]-phenyl}-2-diethylamino-acetamide, particularly useful as cyclin dependent kinase (CDK) inhibitors, pharmaceutical compositions comprising the same and the use thereof in particular in the prophylaxis and/or treatment of cancer and other proliferative diseases. Furthermore, the present invention relates to processes for the synthesis of said 3-aminopyrazolo[3,4d]pyrimidin-4-ones and intermediates to be used in the processes of the present invention.