The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
Jul. 11, 2019
Kala Pharmaceuticals, Inc., Watertown, MA (US);
Winston Zapanta Ong, Stoneham, MA (US);
Pawel Wojciech Nowak, Woodcliff Lake, NJ (US);
Jinsoo Kim, Brighton, MA (US);
Elizabeth M. Enlow, Waltham, MA (US);
James Bourassa, Somerville, MA (US);
Yen Cu, Cambridge, MA (US);
Alexey Popov, Waltham, MA (US);
Hongming Chen, Belmont, MA (US);
Kala Pharmaceuticals, Inc., Watertown, MA (US);
Abstract
The present invention provides novel derivative of β-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. Also provided are particles (e.g., nanoparticles) and pharmaceutical compositions thereof that are mucus penetrating. The inventive particles and pharmaceutical compositions may be useful in delivering an inventive compound to the respiratory tract of a subject. The invention further provides methods of using and kits including the inventive compounds, particles thereof, and/or pharmaceutical compositions thereof for treating and/or preventing a pulmonary disease (e.g., a respiratory tract infection).