The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
May. 25, 2017
Applicant:
Griffith University, Brisbane, AU;
Inventors:
Surendran Mahalingam, Brisbane, AU;
Adam Taylor, Brisbane, AU;
Assignee:
Griffith University, Nathan, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); A61P 31/14 (2006.01); C07K 14/005 (2006.01); C07K 19/00 (2006.01); C07K 7/00 (2006.01); G01N 33/569 (2006.01); A61K 39/42 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/42 (2013.01); A61K 39/12 (2013.01); A61P 31/14 (2018.01); C07K 14/005 (2013.01); C07K 19/00 (2013.01); C12N 7/00 (2013.01); G01N 33/56983 (2013.01); A61K 2039/5254 (2013.01); C07K 2319/09 (2013.01); C12N 2770/36122 (2013.01); C12N 2770/36134 (2013.01); C12N 2770/36162 (2013.01); G01N 2333/181 (2013.01); Y02A 50/30 (2018.01);
Abstract
The invention relates to a vaccine comprising live attenuated recombinant alphavirus comprising mutated capsid protein. The invention also relates to a method of preventing a subject from contracting an alphaviral infection that would otherwise produce clinical signs of disease. In an embodiment the mutated capsid protein is Chikungunya virus (CHIKV) capsid protein having a mutated nucleolar localisation signal/sequence (NoLS), preferably the mutant NLS 101/95.