The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 17, 2021

Filed:

Jun. 27, 2012
Applicants:

Karen Lovetri, Winnipeg, CA;

Srinivasa Madhyastha, Winnipeg, CA;

Nandadeva Yakandawala, Winnipeg, CA;

Purushottam V. Gawande, Winnipeg, CA;

Gord Froehlich, Selkirk, CA;

Inventors:

Karen LoVetri, Winnipeg, CA;

Srinivasa Madhyastha, Winnipeg, CA;

Nandadeva Yakandawala, Winnipeg, CA;

Purushottam V. Gawande, Winnipeg, CA;

Gord Froehlich, Selkirk, CA;

Assignee:

Kane Biotech Inc., Winnipeg, CA;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/40 (2006.01); A61K 31/198 (2006.01); A61K 31/194 (2006.01); A61K 45/06 (2006.01); A61K 8/365 (2006.01); A61K 9/127 (2006.01); A61K 8/44 (2006.01); A61K 8/64 (2006.01); A61Q 17/00 (2006.01); A61K 31/315 (2006.01); A61K 47/60 (2017.01); A61Q 11/00 (2006.01); A61K 9/51 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/40 (2013.01); A61K 8/365 (2013.01); A61K 8/44 (2013.01); A61K 8/64 (2013.01); A61K 9/0063 (2013.01); A61K 9/127 (2013.01); A61K 9/5153 (2013.01); A61K 31/194 (2013.01); A61K 31/198 (2013.01); A61K 31/315 (2013.01); A61K 45/06 (2013.01); A61K 47/60 (2017.08); A61Q 11/00 (2013.01); A61Q 17/005 (2013.01); A61K 2800/51 (2013.01);
Abstract

Compositions comprising iron-sequestering glycoproteins, chelating agents, stabilizing agents, binding agents, surfactants, fluorides, antimicrobials and a pH adjuster or buffer for the prevention and treatment of oral cavity diseases caused by dental plaque/biofilm, such as dental caries, gingivitis and periodontitis, through anti-infective properties are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in polymicrobial dental biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, spray, or other suitable form. Additionally, the invention offers an efficient method of delivering the formulated composition containing a PEGylated or fluorinated iron-sequestering glycoprotein and one or two chelating agents or chelating agents alone using either a liposomal or a nanoparticle delivery system.


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