The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 17, 2021

Filed:

May. 03, 2019
Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

John Gordon Allen, Newbury Park, CA (US);

Jennifer Rebecca Allen, Newbury Park, CA (US);

Ana Elena Minatti, Los Angeles, CA (US);

Qiufen Xue, Thousand Oaks, CA (US);

Ryan Paul Wurz, Newbury Park, CA (US);

Christopher M. Tegley, Daly City, CA (US);

Alexander J. Pickrell, Westlake Village, CA (US);

Thomas T. Nguyen, Newbury Park, CA (US);

Vu Van Ma, Oak Park, CA (US);

Patricia Lopez, Woodland Hills, PA (US);

Longbin Liu, Thousand Oaks, CA (US);

David John Kopecky, Washington, DC (US);

Michael J. Frohn, Thousand Oaks, CA (US);

Ning Chen, Thousand Oaks, CA (US);

Jian Jeffrey Chen, Camarillo, CA (US);

Aaron C. Siegmund, Ventura, CA (US);

Albert Amegadzie, Moorpark, CA (US);

Nuria A. Tamayo, Newbury Park, CA (US);

Shon Booker, Sherman Oaks, CA (US);

Clifford Goodman, Thousand Oaks, CA (US);

Mary Walton, Burlingame, CA (US);

Nobuko Nishimura, West Hills, CA (US);

Youngsook Shin, Thousand Oaks, CA (US);

Jonathan D. Low, Reseda, CA (US);

Victor J. Cee, Thousand Oaks, CA (US);

Anthony B. Reed, Newbury Park, CA (US);

Hui-Ling Wang, Thousand Oaks, CA (US);

Brian Alan Lanman, Woodland Hills, CA (US);

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/517 (2006.01); A61P 35/00 (2006.01); A61K 31/4985 (2006.01); A61K 39/395 (2006.01); C07D 403/04 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/517 (2013.01); A61K 31/4985 (2013.01); A61K 39/39558 (2013.01); A61P 35/00 (2018.01); C07D 403/04 (2013.01); C07D 471/04 (2013.01);
Abstract

Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.


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