The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2021
Filed:
Nov. 13, 2017
Applicant:
Hera Testing Laboratories, Inc., Lexington, KY (US);
Inventors:
Eric M. Ostertag, Del Mar, CA (US);
John Stuart Crawford, Lexington, KY (US);
Joseph Ruiz, Lexington, KY (US);
Assignee:
Hera Testing Laboratories, Inc., Lexington, KY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); C12N 9/12 (2006.01); C12N 9/14 (2006.01); C12N 9/22 (2006.01); C12N 15/85 (2006.01); C12N 15/87 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0276 (2013.01); C12N 9/1205 (2013.01); C12N 9/14 (2013.01); C12N 9/22 (2013.01); C12N 15/8509 (2013.01); C12N 15/87 (2013.01); C12N 15/907 (2013.01); A01K 2217/054 (2013.01); A01K 2217/056 (2013.01); A01K 2217/15 (2013.01); A01K 2217/20 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); A01K 2267/0387 (2013.01); C12N 2015/8536 (2013.01);
Abstract
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.