The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 10, 2021

Filed:

Mar. 09, 2016
Applicant:

University of Kentucky Research Foundation, Lexington, KY (US);

Inventors:

Peixuan Guo, Columbus, OH (US);

Dan Shu, Columbus, OH (US);

Yi Shu, Columbus, OH (US);

Hui Li, Columbus, OH (US);

Farzin Haque, Long Island City, NY (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61K 48/00 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01); C07H 21/02 (2006.01); A61P 35/00 (2006.01); A61K 9/51 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
C12N 15/1135 (2013.01); A61K 9/51 (2013.01); A61P 35/00 (2018.01); C07H 21/02 (2013.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); C12N 15/1138 (2013.01); B82Y 5/00 (2013.01); C12N 2310/11 (2013.01); C12N 2310/12 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2310/16 (2013.01); C12N 2310/52 (2013.01); C12N 2320/30 (2013.01);
Abstract

The presently-disclosed subject matter relates to RNA-based composition and method to treat breast cancer in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure and composition containing a multiple branched RNA nanoparticle, a breast cancer targeting module, and an effective amount of a breast cancer therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanoparticle composition to treat breast cancer in a subject having or at risk of having breast cancer.


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