The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2021
Filed:
Dec. 05, 2019
Applicant:
University of Pittsburgh-of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Inventors:
Yangzi Jiang, Pittsburgh, PA (US);
Rocky S. Tuan, Pittsburgh, PA (US);
Assignee:
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/54 (2006.01); C07K 14/48 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/5428 (2013.01); C07K 14/48 (2013.01); A61K 38/00 (2013.01); C07K 2319/02 (2013.01);
Abstract
Disclosed herein are Nsp-IL10 polypeptides comprising an Nsp polypeptide and an IL10 polypeptide. In some embodiments, Nsp-IL10 polypeptide is capable of activating an NGF signaling pathway, an IL10 signaling pathway, or both. Also disclosed are methods for treating a disease comprising administering an Nsp-IL10 polypeptide. The methods include treating diseases associated with joint inflammation, such as osteoarthritis.