The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2021
Filed:
Aug. 30, 2018
Applicant:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Inventors:
Thazha P. Prakash, Carlsbad, CA (US);
Punit P. Seth, Carlsbad, CA (US);
Eric E. Swayze, Encinitas, CA (US);
Assignee:
Ionis Pharmaceuticals, inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 19/067 (2006.01); C07H 19/167 (2006.01); C07H 19/10 (2006.01); C07H 19/20 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C07H 21/00 (2013.01); C07H 19/067 (2013.01); C07H 19/10 (2013.01); C07H 19/167 (2013.01); C07H 19/20 (2013.01); C07H 21/02 (2013.01); C12N 15/113 (2013.01); C12N 15/1135 (2013.01); C12N 15/1137 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/31 (2013.01); C12N 2310/315 (2013.01); C12N 2310/318 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/345 (2013.01); C12N 2310/346 (2013.01); C12N 2320/30 (2013.01); C12N 2320/51 (2013.01);
Abstract
The present invention provides modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides and analogs thereof that are useful for incorporation at the terminus of an oligomeric compound. Such oligomeric compounds can also be included in a double stranded composition. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.