The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2021
Filed:
Feb. 13, 2020
Applicant:
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Inventors:
Sara S. Hadida Ruah, La Jolla, CA (US);
Matthew M. Hamilton, Hackettstown, NJ (US);
Mark Miller, San Diego, CA (US);
Peter D. J. Grootenhuis, San Diego, CA (US);
Assignee:
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 317/12 (2006.01); C07D 405/12 (2006.01); A61K 31/443 (2006.01); A61K 45/06 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); C07D 405/14 (2006.01); A61K 31/47 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); A61K 31/443 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 317/12 (2013.01); C07D 405/14 (2013.01);
Abstract
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.