The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2021
Filed:
Oct. 11, 2018
Applicant:
Drexel University, Philadelphia, PA (US);
Inventors:
Kara L. Spiller, Philadelphia, PA (US);
Sina Nassiri, Philadelphia, PA (US);
Assignee:
Drexel University, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); A61L 26/00 (2006.01); A61L 27/20 (2006.01); A61L 27/56 (2006.01); C08L 5/04 (2006.01); C08L 5/08 (2006.01); C08L 89/00 (2006.01); C08L 89/04 (2006.01);
U.S. Cl.
CPC ...
A61L 26/0066 (2013.01); A61K 38/2026 (2013.01); A61K 38/2066 (2013.01); A61L 26/008 (2013.01); A61L 26/0023 (2013.01); A61L 26/0038 (2013.01); A61L 26/0047 (2013.01); A61L 27/20 (2013.01); A61L 27/56 (2013.01); C08L 5/04 (2013.01); C08L 5/08 (2013.01); C08L 89/00 (2013.01); C08L 89/04 (2013.01); A61L 2300/252 (2013.01); A61L 2300/258 (2013.01); A61L 2300/426 (2013.01); A61L 2300/608 (2013.01); A61L 2300/622 (2013.01);
Abstract
One aspect of the invention provides a method of sequentially inducing macrophage conversion in a wound. The method includes: (a) administering IL-4 to induce conversion of a first population of wound macrophages in the wound to M2A macrophages; and then (b) administering IL-10, dexamethasone, or a dexamethasone analog to induce conversion of a second population of wound macrophages in the wound to M2C macrophages.