The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2021
Filed:
Jan. 29, 2019
Applicant:
Genzyme Corporation, Cambridge, MA (US);
Inventors:
Alejandra E. Arbetman, Bridgewater, NJ (US);
Peter C. Colosi, Bridgewater, NJ (US);
Michael A. Lochrie, Bridgewater, NJ (US);
Richard T. Surosky, Bridgewater, NJ (US);
Assignee:
Genzyme Corporation, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 38/48 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 38/4846 (2013.01); A61K 48/00 (2013.01); A61K 48/0058 (2013.01); A61K 48/0075 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12Y 304/21022 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14162 (2013.01); C12N 2830/008 (2013.01); C12N 2830/85 (2013.01);
Abstract
Methods of making and using recombinant AAV virions with decreased immunoreactivity are described. The recombinant AAV virions include mutated capsid proteins or are derived from non-primate mammalian AAV serotypes and isolates that display decreased immunoreactivity relative to AAV-2.