The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 10, 2021

Filed:

Mar. 18, 2016
Applicants:

Mie University, Tsu, JP;

Kyoto University, Kyoto, JP;

Inventors:

Hiroshi Shiku, Tsu, JP;

Naohiro Seo, Tsu, JP;

Kazunari Akiyoshi, Kyoto, JP;

Naozumi Harada, Tsu, JP;

Fumiyasu Momose, Tsu, JP;

Assignees:

MIE UNIVERSITY, Tsu, JP;

KYOTO UNIVERSITY, Kyoto, JP;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/7105 (2006.01); A61P 35/00 (2006.01); A61K 35/17 (2015.01); C12Q 1/6876 (2018.01); C12N 5/0775 (2010.01); A61K 9/08 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 35/17 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C12N 5/0663 (2013.01); C12Q 1/6876 (2013.01); C12N 2503/02 (2013.01); C12Q 2600/178 (2013.01);
Abstract

Therapeutic agents effective for treating cell-proliferative diseases contain extracellular vesicles (exosomes) released from cytotoxic T cells or miRNA obtained from extracellular vesicles (exosomes) released from cytotoxic T cells, such as human CD8+ T cells. Such therapeutic agents suppress the proliferation of mesenchymal cells surrounding cancer cells, e.g., by killing the mesenchymal cells, such that the cancer cells become isolated and unable to metastasize. Cell-proliferative diseases are thus treatable by administering such a therapeutic agent to a patient.


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