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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11083727 B1

PDFFull Text
Date of Patent:
Aug. 10, 2021

Filed:

Dec. 27, 2018

Piperidine-substituted mnk inhibitors and methods related thereto

Applicant:

Effector Therapeutics Inc., San Diego, CA (US);

Inventors:

Justin T. Ernst, San Diego, CA (US);

Paul A. Sprengeler, Escondido, CA (US);

Siegfried H. Reich, La Jolla, CA (US);

Samuel Sperry, Encinitas, CA (US);

Assignee:

eFFECTOR Therapeutics Inc., San Diego, CA (US);

Attorney:

Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 471/20 (2006.01); C07D 487/04 (2006.01); C07D 491/20 (2006.01); C07D 495/20 (2006.01); A61K 31/506 (2006.01); A61P 29/00 (2006.01); A61P 35/02 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61P 29/00 (2018.01); A61P 35/02 (2018.01);
Abstract

The present invention relates to compounds according to Formula (I): or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof wherein X, X, R, R, Rand n are as defined herein. Also described are pharmaceutically acceptable compositions of Formula (I) compounds as well as methods for utilizing the compounds of Formula (I) and the pharmaceutically acceptable compositions of Formula (I) compounds as inhibitors of Mnk as well as therapeutics for the treatment of diseases such as cancer.

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