The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 10, 2021
Filed:
Aug. 23, 2019
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Ethan Bier, San Diego, CA (US);
Annabel Guichard, La Jolla, CA (US);
Victor Nizet, San Diego, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/42 (2006.01); A61K 31/277 (2006.01); A61K 31/4196 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/42 (2013.01); A61K 9/0019 (2013.01); A61K 9/0095 (2013.01); A61K 31/277 (2013.01); A61K 31/4196 (2013.01);
Abstract
Methods and pharmaceutical compositions for treating diseases characterized by compromised epithelial or endothelial barrier integrity are provided. The pharmaceutical compositions include an effective amount a Epac/Rap1 signaling inhibitor. The methods include administering to a patient suffering from a disease characterized by compromised epithelial or endothelial barrier integrity a therapeutically effective amount of a Epac/Rap1 signaling inhibitor, such as ESI-09, SecinH3, Slit, or AG1024.