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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11081235 B1

PDFFull Text
Date of Patent:
Aug. 03, 2021

Filed:

Jun. 05, 2019

Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies

Applicants:

Mor-research Applications Ltd., Tel Aviv, IL;

Technion Research and Development Foundation Ltd., Haifa, IL;

Inventors:

Michal A. Rahat, Haifa, IL;

Nitza Lahat, Atlit, IL;

Miriam Walter, Nesher, IL;

Haim Bitterman, Haifa, IL;

Assignees:

MOR-RESEARCH APPLICATIONS LTD., Tel Aviv, IL;

TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD., Haifa, IL;

Attorney:

J.A. Lindeman & Co., PLLC

Primary Examiner:

Maher M Haddad

Int. Cl.
CPC ...
A61K 39/00 (2006.01); G16H 50/30 (2018.01); C07K 16/28 (2006.01); C07K 14/705 (2006.01); C12N 15/62 (2006.01); G01N 33/574 (2006.01); C07K 14/435 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
G16H 50/30 (2018.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 14/435 (2013.01); C07K 14/705 (2013.01); C07K 16/2803 (2013.01); C12N 15/62 (2013.01); G01N 33/57484 (2013.01); G01N 33/68 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/34 (2013.01); C07K 2317/76 (2013.01); G01N 2333/70596 (2013.01); Y02A 90/10 (2018.01);
Abstract

The invention provides isolated peptides from the protein EMMPRIN (CD147/Basigin) and antibodies directed against antigenic determinants within said peptides. Pharmaceutical compositions comprising said peptides and antibodies are also disclosed as well as methods of their production and use in vaccination, immunotherapy and diagnosis of proliferative, hyperpermeability, inflammatory, and angiogenesis-related diseases and disorders.

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