System and method for proton density mapping and receiver bias correction using magnetic resonance fingerprinting (mrf)

Abstract

A system and method is provided for correcting receiver bias during quantitative proton density mapping with magnetic resonance fingerprinting (MRF). The method comprises acquiring MRF data from a region of interest in a subject by performing a pulse sequence using a series of varied sequence blocks to elicit a series of signal evolutions. The method further comprises comparing the MRF data to a MRF dictionary to simultaneously map proton density and another tissue property from the region of interest, the proton density map having a proton density signal and a receiver sensitivity profile signal. The method also includes quantifying the proton density signal and the receiver sensitivity profile signal using parameters provided by the proton density map and the tissue property map, and generating a quantitative map from the region of interest based on the proton density signal.