The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Apr. 18, 2016
Applicant:
Biogen MA Inc., Cambridge, MA (US);
Inventor:
Alissa A. Chackerian, Sunnyvale, CA (US);
Assignee:
BIOGEN MA INC., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); G01N 33/566 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); C07K 16/2839 (2013.01); G01N 33/566 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01); G01N 2333/7056 (2013.01); G01N 2333/70503 (2013.01); G01N 2333/70546 (2013.01); G01N 2500/00 (2013.01); G01N 2800/52 (2013.01);
Abstract
Provided herein is a method of monitoring the change of the alpha-4 integrin activities in an individual by correlating with the soluble vascular cell adhesion molecule (sVCAM) and/or soluble mucosal addressin cell adhesion molecule (sMAdCAM) levels. Particularly, this method can be used, for example, to evaluate the pharmacokinetics and pharmacodynamics (PK/PD) of an alpha-4 integrin inhibitor used to treat a disease associated with pathological or chronic inflammation.