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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11079382 B1

PDFFull Text
Date of Patent:
Aug. 03, 2021

Filed:

Aug. 24, 2016

Methods, kits, and systems for scoring the immune response to cancer

Applicant:

Ventana Medical Systems, Inc., Tucson, AZ (US);

Inventors:

Noemi Sebastiao, Tucson, AZ (US);

William Day, Tucson, AZ (US);

Robert Ochs, Oro Valley, AZ (US);

Srinivas Chukka, San Jose, CA (US);

Jim Martin, Mountain View, CA (US);

Michael Barnes, San Francisco, CA (US);

Joerg Bredno, San Francisco, CA (US);

Ting Chen, Sunnyvale, CA (US);

Alisa Tubbs, Phoenix, AZ (US);

Yao Nie, Sunnyvale, CA (US);

Assignee:

Ventana Medical Systems, Inc, Tucson, AZ (US);

Attorney:

Ventana Medical Systems, Inc.

Primary Examiner:

Michael L Borin

Int. Cl.
CPC ...
G01N 33/574 (2006.01); G01N 15/14 (2006.01); G06F 19/20 (2011.01); G16B 25/00 (2019.01); G01N 33/68 (2006.01); G01N 33/566 (2006.01); G16B 25/10 (2019.01); G01N 35/00 (2006.01); G01N 15/00 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5743 (2013.01); G01N 15/1463 (2013.01); G01N 33/566 (2013.01); G01N 33/574 (2013.01); G01N 33/57415 (2013.01); G01N 33/6875 (2013.01); G01N 35/00029 (2013.01); G16B 25/00 (2019.02); G16B 25/10 (2019.02); G01N 2015/008 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1486 (2013.01); G01N 2035/00138 (2013.01); G01N 2333/4703 (2013.01); G01N 2333/4739 (2013.01); G01N 2333/4742 (2013.01); G01N 2333/7051 (2013.01); G01N 2333/70503 (2013.01); G01N 2333/70517 (2013.01);
Abstract

This disclosure describes methods, kits, and systems for scoring the immune response to cancer through examination of tissue infiltrating lymphocytes (TILs). Methods of scoring the immune response in cancer using tissue infiltrating lymphocytes include detecting CD3, CD8, CD20, and FoxP3 within the sample and scoring the detection manually or scoring the digital images of the staining with the aid of image analysis and algorithms.

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