The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 03, 2021

Filed:

Jan. 03, 2017
Applicant:

King Abdullah University of Science and Technology, Thuwal, SA;

Inventors:

Jürgen Kosel, Thuwal, SA;

Mincho Nikolaev Kavaldzhiev, Thuwal, SA;

Jose Efrain Perez, Thuwal, SA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/26 (2006.01); B81B 1/00 (2006.01); A61B 10/02 (2006.01); A61B 5/00 (2006.01); A61B 10/00 (2006.01); B81C 1/00 (2006.01); A61M 37/00 (2006.01); C12M 1/00 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
C12M 1/26 (2013.01); A61B 5/685 (2013.01); A61B 10/0045 (2013.01); A61B 10/0233 (2013.01); A61M 37/0015 (2013.01); B81B 1/008 (2013.01); B81C 1/00111 (2013.01); C12M 23/20 (2013.01); A61B 2010/0225 (2013.01); A61M 2037/003 (2013.01); A61M 2037/0023 (2013.01); A61M 2037/0053 (2013.01); B81B 2201/055 (2013.01); B82Y 5/00 (2013.01);
Abstract

Nanoneedles and nanoneedle arrays and methods of making nanoneedles are provided. The methods can include multilayer fabrication methods using a negative photoresist and/or a positive photoresist. The nanoneedle arrays include one or more nanoneedles attached to a surface of a substrate. The nanoneedle can have both a proximal opening and a distal opening, and an inner passageway connecting the proximal opening and the distal opening. The nanoneedle can have a functional coating. The nanoneedle can include iron, cobalt, nickel, gold, and oxides and alloys thereof. The nanoneedle arrays can be used for the administration and/or the extraction of agents from individual cells. In one or more aspects, the nanoneedles can be magnetic nanoneedles. An oscillating magnetic field applied to a magnetic nanoneedle can induce one or both of heating and vibration of the magnetic nanoneedle. The heating and/or vibration can cause a magnetic nanoneedle to penetrate the wall of a cell.


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