The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Nov. 02, 2018
Medimmune Limited, Cambridge, GB;
Andrew Buchanan, Cambridge, GB;
Matthieu Chodorge, Cambridge, GB;
Peter Cariuk, Cambridge, GB;
Johanna Husmark, Macclesfield, GB;
Clare Balendran, Molndal, SE;
Deepesh Pandey, Baltimore, MD (US);
Fumin Chang, Baltimore, MD (US);
Daniel E. Berkowitz, Baltimore, MD (US);
Lewis H. Romer, Baltimore, MD (US);
MedImmune Limited, Cambridge, GB;
Abstract
This disclosure provides LOX1 (LOX1) binding proteins such as anti-LOX1 antibodies, and compositions and methods for making these binding proteins. In certain aspects the LOX1-binding proteins provided herein, inhibit, or antagonize LOX1 activity. In addition, the disclosure provides compositions and methods for diagnosing and treating conditions associated with atherosclerosis, thrombosis, coronary artery disease (CAD), ischemia (e.g., myocardial ischemia), infarction (e.g., myocardial infarction), acute coronary syndrome (ACS), stroke, reperfusion injury, restenosis, peripheral vascular disease, hypertension, heart failure, inflammation (e.g., chronic inflammation), angiogenesis, preeclampsia, cancer and other LOX1-mediated diseases and conditions.