The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 03, 2021

Filed:

Feb. 01, 2017
Applicants:

Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;

Universite Paul Sabatier Toulouse Iii, Toulouse, FR;

Centre Hospitalier Universitaire DE Toulouse, Toulouse, FR;

Inventors:

Thierry Levade, Toulouse, FR;

Bruno Segui, Toulouse, FR;

Florie Bertrand, Toulouse, FR;

Julia Rochotte, Toulouse, FR;

Anne Montfort, Toulouse, FR;

Nathalie Andrieu-Abadie, Toulouse, FR;

Celine Colacios Viatge, Toulouse, FR;

Nicolas Meyer, Toulouse, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61P 35/00 (2006.01); C12N 15/86 (2006.01); C07K 16/28 (2006.01); A61K 38/46 (2006.01); A61K 31/713 (2006.01); A61K 39/00 (2006.01); A61K 9/127 (2006.01); C12N 9/16 (2006.01); G01N 33/569 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2815 (2013.01); A61K 9/127 (2013.01); A61K 31/713 (2013.01); A61K 38/465 (2013.01); A61K 39/001111 (2018.08); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); C12N 9/16 (2013.01); C12Y 301/04012 (2013.01); G01N 33/56972 (2013.01); A61K 2039/505 (2013.01); G01N 2333/70517 (2013.01);
Abstract

The present invention relates to methods and pharmaceutical compositions for enhancing CD8+ T cell-dependent immune responses in subjects suffering from cancer. In particular, the present invention relates to a method of enhancing the CD8+ T cell-dependent immune response in a subject suffering from cancer comprising administering to the subject a therapeutically effective amount of an agent capable of increasing intra-tumoral ceramide content.


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