The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Oct. 25, 2017
The United States of America, As Represented BY the Secretary, Dept. of Health and Human Services, Bethesda, MD (US);
Institute for Research IN Biomedicine, Bellinzona, CH;
Baoshan Zhang, Bethesda, MD (US);
Guillaume Stewart-Jones, Bethesda, MD (US);
Tongqing Zhou, Boyds, MD (US);
John Mascola, Rockville, MD (US);
Kai Xu, Bethesda, MD (US);
Yongping Yang, Potomac, MD (US);
Paul Thomas, Washington, DC (US);
Gwo-Yu Chuang, Rockville, MD (US);
Li Ou, Bethesda, MD (US);
Peter Kwong, Washington, DC (US);
Yaroslav Tsybovsky, Jefferson, MD (US);
Wing-Pui Kong, Germantown, MD (US);
Aliaksandr Druz, Germantown, MD (US);
Davide Corti, Bellinzona, CH;
Antonio Lanzavecchia, Bellinzona, CH;
The United States of America, as represented by the Secretary, Dept. of Health and Human Services, Bethesda, MD (US);
Institute for Research in Biomedicine, Bellinzona, CH;
Abstract
Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.