The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Jan. 16, 2018
Applicant:
Yafei Shanghai Biology Medicine Science & Technology Co. Ltd., Shanghai, CN;
Inventors:
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 5/08 (2006.01); C07K 5/083 (2006.01); A61K 47/65 (2017.01); A61K 47/54 (2017.01); A61P 35/00 (2006.01); A61K 31/44 (2006.01); C07D 213/81 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 5/0806 (2013.01); A61K 31/44 (2013.01); A61K 47/54 (2017.08); A61K 47/65 (2017.08); A61P 35/00 (2018.01); C07D 213/81 (2013.01); C07K 5/081 (2013.01); C07K 5/0808 (2013.01); A61K 45/06 (2013.01);
Abstract
Disclosed are molecularly targeted and activated kinase inhibitors and use thereof. Specifically, a compound represented by the following formula A or a pharmaceutically acceptable salt thereof, wherein X is a polar and a non-polar uncharged amino acid such as alanine, proline or threonine; A is alanine; N is asparagine; PABC is —NH-phenyl-CH2-O—; and Z is a drug molecule; wherein the lactobionic acid residue, XAN and PABC are linked to each other by an amide bond; PABC is bonded to Z by an ester group, i.e., —OC(O)—.