The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 03, 2021

Filed:

Nov. 07, 2019
Applicant:

Eidos Therapeutics, Inc., San Francisco, CA (US);

Inventors:

Pooran Chand, San Francisco, CA (US);

Yogesh Kumar Gupta, San Francisco, CA (US);

Rakesh Kumar Kumawat, San Francisco, CA (US);

Mamoun Alhamadsheh, San Francisco, CA (US);

Robert Zamboni, San Francisco, CA (US);

Assignee:

EIDOS THERAPEUTICS, INC., San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/12 (2006.01); C07C 309/04 (2006.01); C07C 309/30 (2006.01);
U.S. Cl.
CPC ...
C07D 231/12 (2013.01); C07C 309/04 (2013.01); C07C 309/30 (2013.01); C07B 2200/13 (2013.01);
Abstract

Provided herein are improved processes for the preparation of a compound of Formula IX (AG-10). Also provided herein are pharmaceutically acceptable salts of Formula I and Formula Ib as well as crystalline types of Formula IX (AG-10). The processes described herein provide improved yields and efficiency, while the pharmaceutically acceptable salts and crystalline forms provide unexpected pharmacokinetic properties. Other features and aspects of the present disclosure will be apparent to a person of skill in the art upon reading the remainder of the specification.


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