The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 03, 2021

Filed:

Jul. 08, 2014
Applicant:

Multi-magnetics Incorporated, London, CA;

Inventors:

Donna E. Goldhawk, London, CA;

D. James Koropatnick, London, CA;

Rene Figueredo, London, CA;

Frank S. Prato, London, CA;

R. Terry Thompson, London, CA;

Neil Gelman, London, CA;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/195 (2006.01); A61K 49/18 (2006.01); C12N 15/85 (2006.01); C12Q 1/6883 (2018.01); C12Q 1/689 (2018.01);
U.S. Cl.
CPC ...
A61K 49/1896 (2013.01); C07K 14/195 (2013.01); C12N 15/85 (2013.01); C12Q 1/689 (2013.01); C12Q 1/6883 (2013.01); C12N 2510/00 (2013.01);
Abstract

The invention provides an improved modified magnetosome that contains more iron therein with the combination of the expressed genes. This is achieved by co-expression of (a) one or more bacterial magnetotactic genes to amplify iron uptake, compartmentalization and biomineralization in cells, with (b) one or more mammalian iron handling proteins that together augment(s) and/or regulate the cells iron pool. As a result, mammalian cells or bacterial cells that are transfected or transformed, respectively, can be more effectively tracked using various imaging technologies.


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