The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Nov. 15, 2016
Oklahoma Medical Research Foundation, Oklahoma City, OK (US);
Xiao-Yan Zhao, Union City, CA (US);
Andreas Wilmen, Cologne, DE;
Christoph Freiberg, Wuppertal, DE;
Lars Linden, Gevelsberg, DE;
Ji-Yun Kim, Berkeley, CA (US);
Subramanian Yegneswaran, Pleasanton, CA (US);
Karin Regnstrom, San Francisco, CA (US);
Ursula Egner, Berlin, DE;
Xinquan Wang, Beijing, CN;
OKLAHOMA MEDICAL RESEARCH FOUNDATION, Oklahoma City, OK (US);
Abstract
Provided are optimized humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. In particular, the antibodies bind to particular epitopes outside the catalytic triad of the active site of human activated protein C. Methods of treatment employing these antibodies are described herein.