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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11077145 B1

PDFFull Text
Date of Patent:
Aug. 03, 2021

Filed:

Apr. 01, 2016

Method for mass producing proteins in mesenchymal stem cells

Applicant:

Stemmedicare Co., Ltd., Seoul, KR;

Inventor:

Jang Ho Lee, Seoul, KR;

Assignee:

STEMMEDICARE CO., LTD., Seoul, KR;

Attorneys:

Novick, Kim & Lee, PLLC

Sang Ho Lee

Primary Examiner:

Teresa E Knight

Int. Cl.
CPC ...
A61K 35/28 (2015.01); C07K 14/50 (2006.01); C07K 14/525 (2006.01); C07K 14/475 (2006.01); C07K 14/49 (2006.01); C07K 14/78 (2006.01); C07K 14/435 (2006.01); C07K 14/54 (2006.01); C12N 5/00 (2006.01); C07K 14/47 (2006.01); A61P 17/16 (2006.01); A61K 9/00 (2006.01); A61K 38/39 (2006.01); C07K 14/545 (2006.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61K 9/0014 (2013.01); A61K 38/39 (2013.01); A61P 17/16 (2018.01); C07K 14/435 (2013.01); C07K 14/47 (2013.01); C07K 14/475 (2013.01); C07K 14/49 (2013.01); C07K 14/50 (2013.01); C07K 14/525 (2013.01); C07K 14/54 (2013.01); C07K 14/545 (2013.01); C07K 14/5409 (2013.01); C07K 14/78 (2013.01); C12N 5/00 (2013.01); C12N 5/0031 (2013.01);
Abstract

The present invention relates to the method for mass production of mesenchymal stem cell-derived proteins including various growth factors and cytokines, a mesenchymal stem cell conditioned medium containing a large amount of protein and produced by the above production method, cosmetic composition and pharmaceutical composition including the above conditioned medium for skin regeneration, anti-wrinkle, alopecia treatment, prevention of hair loss and promotion of hair growth. The method for mass production of the mesenchymal stem cell-derived protein of the present invention can greatly increase the amount of various growth factors and proteins which are known to be not expressed from mesenchymal stem cells or expressed only in very small amounts by the existing culture method, and the mesenchymal stem cell conditioned medium prepared by the above method contains a large amount of various kinds of cytokines and growth factors so that it has the excellent effect on skin regeneration, wrinkle improvement, prevention of hair loss, alopecia treatment and hair growth promotion.

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