The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Aug. 01, 2019
Applicant:
Nantkwest, Inc., San Diego, CA (US);
Inventors:
Hans G. Klingemann, San Diego, CA (US);
Laurent H. Boissel, San Diego, CA (US);
Abhijit Dandapat, San Diego, CA (US);
Assignee:
NantKwest Inc., San Diego, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61P 35/00 (2006.01); C07K 14/735 (2006.01); C07K 14/725 (2006.01); A61P 35/04 (2006.01); C07K 14/54 (2006.01); C07K 16/28 (2006.01); C07K 14/55 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61P 35/04 (2018.01); C07K 14/5443 (2013.01); C07K 14/55 (2013.01); C07K 14/7051 (2013.01); C07K 14/70535 (2013.01); C07K 16/2827 (2013.01);
Abstract
Provided herein are compositions of NK-92™ cells that express a combination of PD-L1 CAR, CD16 and IL2, and the method of using these cells to reduce tumor cells and cells in tumor microenvironment (e.g., MDSCs or TAMs) and treat cancer.