The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Feb. 04, 2016
Applicant:
F. Hoffmann-la Roche Ag, Basel, CH;
Inventors:
Richard E. Olson, Wallingford, CT (US);
Angela M. Cacace, Higganum, CT (US);
Peter Hagedorn, Hørsholm, DK;
Anja Mølhart Høg, Hillerød, DK;
Marianne Lerbech Jensen, Koge, DK;
Niels Fisker Nielsen, Kgs. Lyngby, DK;
Dong Li, Wallingford, CT (US);
Jeffrey M. Brown, Medway, MA (US);
Stephen E. Mercer, Wallingford, CT (US);
Assignee:
F. HOFFMANN-LA ROCHE AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/712 (2006.01); C12N 15/113 (2010.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/712 (2013.01); A61P 25/28 (2018.01); C12N 15/113 (2013.01); A61K 2121/00 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/341 (2013.01); C12N 2310/343 (2013.01); C12N 2310/346 (2013.01);
Abstract
The present invention relates to oligomer compounds (oligomers), which target Tau mRNA in a cell, leading to reduced expression of Tau protein. Reduction of Tau protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.