The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Sep. 26, 2014
Applicant:
Duke University, Durham, NC (US);
Inventors:
Barton F. Haynes, Durham, NC (US);
Sallie Permar, Durham, NC (US);
M. Anthony Moody, Durham, NC (US);
Feng Gao, Durham, NC (US);
Hua-Xin Liao, Durham, NC (US);
Georgia Tomaras, Durham, NC (US);
David C. Montefiori, Durham, NC (US);
Assignee:
DUKE UNIVERSITY, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/21 (2006.01); A61K 31/7088 (2006.01); G01N 33/569 (2006.01); A61K 39/395 (2006.01); C07K 14/16 (2006.01); C07K 14/005 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7088 (2013.01); A61K 39/21 (2013.01); A61K 39/395 (2013.01); C07K 14/005 (2013.01); C07K 14/162 (2013.01); G01N 33/56988 (2013.01); C12N 2740/16111 (2013.01); C12N 2770/00041 (2013.01); G01N 2800/50 (2013.01);
Abstract
The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.