The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Apr. 14, 2020
Applicant:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Inventors:
Steven J. D. Karlish, Rehovot, IL;
Adriana Katz, Rehovot, IL;
Daniel M. Tal, Rehovot, IL;
Arie Marcovich, Rehovot, IL;
Assignee:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7052 (2006.01); C07H 17/00 (2006.01); C07J 43/00 (2006.01); A61P 27/06 (2006.01); A61P 9/00 (2006.01); C07J 19/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7052 (2013.01); A61P 9/00 (2018.01); A61P 27/06 (2018.01); C07H 17/00 (2013.01); C07J 43/003 (2013.01); C07J 19/005 (2013.01);
Abstract
Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.