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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11077108 B1

PDFFull Text
Date of Patent:
Aug. 03, 2021

Filed:

Sep. 06, 2017

Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition

Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Mohammad Parvez Alam, Los Angeles, CA (US);

Varghese John, Los Angeles, CA (US);

Barbara Jagodzinska, Redwood City, CA (US);

Assignee:

The Regents of the University of California, Oakland, CA (US);

Attorneys:

Helen S. Baca

Tom Hunter

Weaver Austin Villeneuve & Sampson LLP

Primary Examiner:

Emily A Bernhardt

Int. Cl.
CPC ...
C07D 239/47 (2006.01); C07D 239/48 (2006.01); A61K 31/506 (2006.01); A61P 25/28 (2006.01); A61K 9/00 (2006.01); C07D 405/12 (2006.01); C07D 239/34 (2006.01); C07D 403/12 (2006.01); C07D 239/52 (2006.01); A61K 31/505 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 9/0053 (2013.01); A61K 31/505 (2013.01); A61P 25/28 (2018.01); C07D 239/34 (2013.01); C07D 239/47 (2013.01); C07D 239/52 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); A61K 45/06 (2013.01);
Abstract

In various embodiments novel allosteric antagonists of the CRFR1 receptor are provided. It discovered that allosteric CRFR1 receptor antagonists are effective to modulate p-Tau levels in Alzheimer's disease (AD) models. In one illustrative embodiment, a compound that is a CRFR1 receptor antagonist is a compound according to the formula or a pharmaceutically acceptable salt, ester, amide, solvate, or prodrug thereof.

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Alam, Mohammad. (2021). Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition (U.S. Patent No. 11077108). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11077108

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