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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11073509 B1

PDFFull Text
Date of Patent:
Jul. 27, 2021

Filed:

Jun. 10, 2016

Assays and methods for determining the responsiveness of an individual subject to a therapeutic agent

Applicant:

Celcuity Inc., Minneapolis, MN (US);

Inventors:

Lance Gavin Laing, Orono, MN (US);

Brian Francis Sullivan, Medina, MN (US);

Assignee:

Celcuity Inc., Minneapolis, MN (US);

Attorneys:

Nelson Mullins Riley & Scarborough LLP

Jane E. Remillard, Esq.

Primary Examiner:

Karen A Canella

Int. Cl.
CPC ...
G01N 33/50 (2006.01); A61K 31/337 (2006.01); A61K 31/4709 (2006.01); A61K 31/4745 (2006.01); A61K 31/506 (2006.01); A61K 31/513 (2006.01); A61K 31/517 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61K 31/555 (2006.01); A61K 31/7068 (2006.01); A61K 33/24 (2019.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); A61K 39/00 (2006.01); C12Q 1/6886 (2018.01);
U.S. Cl.
CPC ...
G01N 33/5011 (2013.01); A61K 31/337 (2013.01); A61K 31/4709 (2013.01); A61K 31/4745 (2013.01); A61K 31/506 (2013.01); A61K 31/513 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/555 (2013.01); A61K 31/7068 (2013.01); A61K 33/24 (2013.01); A61K 39/39558 (2013.01); C07K 16/2863 (2013.01); C07K 16/32 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5008 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C12Q 2600/106 (2013.01); G01N 2800/52 (2013.01);
Abstract

Provided herein are methods for determining the functional status of a cellular pathway in a diseased cell sample obtained from an individual subject. These methods involve contacting a diseased cell sample obtained from the subject with a perturbing agent (e.g., an activating agent) known to perturb a specific cellular pathway when the pathway is functioning normally. A change in one or more physiological response parameters in the presence of the perturbing agent indicates that the cellular pathway targeted by the perturbing agent is functional in the individual subject. Methods of selecting a targeted therapeutic agent for an individual subject are also provided.

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