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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11072790 B1

PDFFull Text
Date of Patent:
Jul. 27, 2021

Filed:

Dec. 20, 2017

Directed evolution through mutation rate modulation

Applicant:

Peter B. Reintjes, Durham, NC (US);

Inventor:

Peter B. Reintjes, Durham, NC (US);

Assignee:

Other;

Attorneys:

Daniel Cole

Olive Law Group, PLLC

Primary Examiner:

Nancy J Leith

Int. Cl.
CPC ...
C12N 15/10 (2006.01); C07K 14/005 (2006.01); C12N 15/01 (2006.01); C12N 15/70 (2006.01); C40B 30/06 (2006.01); C40B 10/00 (2006.01); C12N 7/02 (2006.01); G01N 33/574 (2006.01); G01N 33/68 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1058 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 7/02 (2013.01); C12N 15/01 (2013.01); C12N 15/70 (2013.01); C40B 10/00 (2013.01); C40B 30/06 (2013.01); G01N 33/574 (2013.01); G01N 33/6893 (2013.01); C12N 2795/14121 (2013.01); C12N 2795/14151 (2013.01); C12N 2795/14152 (2013.01); C12N 2800/101 (2013.01);
Abstract

The present invention relates to methods and systems for the directed evolution of macromolecules. The methods involve increasing the mutation rate of an evolving organism comprising a gene of interest that encodes a gene product lacking a desired activity, whereby a mutated gene of interest is produced that encodes an evolved gene product comprising the desired activity and causing a suppression of mutagenesis. The systems comprise an evolving organism comprising a gene of interest encoding a gene product to be evolved, a host organism, and optionally, a lagoon, a cellstat and/or a suitable growth medium.

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Reintjes, Peter. (2021). Directed evolution through mutation rate modulation (U.S. Patent No. 11072790). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11072790

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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