The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 27, 2021
Filed:
Oct. 29, 2018
Ana Romo, Buenos Aires, AR;
Anabela Belen LA Colla, Buenos Aires, AR;
Matias Adan Preisegger, Buenos Aires, AR;
Marcela Soledad Bertolio, Buenos Aires, AR;
Ricardo Alfredo Dewey, Buenos Aires, AR;
Pamela Daiana Vazquez, Buenos Aires, AR;
Andrea Nancy Chisari, Buenos Aires, AR;
Tania Melina Rodriguez, Buenos Aires, AR;
Benito Jorge Velasco Zamora, Buenos Aires, AR;
Ana Romo, Buenos Aires, AR;
Anabela Belen La Colla, Buenos Aires, AR;
Matias Adan Preisegger, Buenos Aires, AR;
Marcela Soledad Bertolio, Buenos Aires, AR;
Ricardo Alfredo Dewey, Buenos Aires, AR;
Pamela Daiana Vazquez, Buenos Aires, AR;
Andrea Nancy Chisari, Buenos Aires, AR;
Tania Melina Rodriguez, Buenos Aires, AR;
Benito Jorge Velasco Zamora, Buenos Aires, AR;
Onsejo Nacional DE Investigation Cientiticay Tecnica, Buenos Aires, AR;
Fundocion Articula, Buenos Aires, AR;
Abstract
An isoform of the TGF beta receptor II comprising a sequence of about of 80 amino acids and lacking a transmembrane domain. The isoform comprises the amino acid sequence set forth in SEQ ID No. 12. The isoform may have the amino acid sequence set forth in SEQ ID No. 2 or sequences having at least 85% sequence identity to the sequence set forth in SEQ ID No. 2. A fusion peptide is provided comprising an isoform of the TGF beta II receptor fused to a ligand, wherein a vector comprising the fusion peptide is used to treat cancer and/or hepatic fibrosis. An antibody binding the soluble isoform of the TGF beta II receptor is provided. The antibody binds the amino acid sequence shown in SEQ ID No. 12 and is used in in vitro methods.