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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11072632 B1

PDFFull Text
Date of Patent:
Jul. 27, 2021

Filed:

Mar. 26, 2012

Inhibitors of 17β-hsd1, 17β-hsd3 and 17β-hsd10

Applicants:

Donald Poirier, L 'Ancienne-Lorette, CA;

Jenny Roy, Saint-Jean-Chrysostome, CA;

Rene Maltais, Quebec, CA;

Inventors:

Donald Poirier, L 'Ancienne-Lorette, CA;

Jenny Roy, Saint-Jean-Chrysostome, CA;

Rene Maltais, Quebec, CA;

Assignee:

UNIVERSITÉ LAVAL, Québec, CA;

Attorney:

Parker Highlander PLLC

Primary Examiner:

Barbara P Badio

Int. Cl.
CPC ...
C07J 41/00 (2006.01); A61K 31/567 (2006.01); A61K 31/58 (2006.01); A61K 51/04 (2006.01); A61K 31/566 (2006.01); A61K 31/69 (2006.01); A61K 31/675 (2006.01); C07J 51/00 (2006.01); C07J 1/00 (2006.01); A61K 31/5685 (2006.01); A61K 45/06 (2006.01); C07J 43/00 (2006.01); C07J 21/00 (2006.01); C07J 31/00 (2006.01);
U.S. Cl.
CPC ...
C07J 41/0005 (2013.01); A61K 31/566 (2013.01); A61K 31/567 (2013.01); A61K 31/5685 (2013.01); A61K 31/58 (2013.01); A61K 31/675 (2013.01); A61K 31/69 (2013.01); A61K 45/06 (2013.01); A61K 51/04 (2013.01); C07J 1/0007 (2013.01); C07J 1/0062 (2013.01); C07J 41/0011 (2013.01); C07J 41/0038 (2013.01); C07J 41/0072 (2013.01); C07J 43/003 (2013.01); C07J 43/006 (2013.01); C07J 51/00 (2013.01); C12Y 101/01051 (2013.01); C07J 21/00 (2013.01); C07J 21/008 (2013.01); C07J 31/006 (2013.01);
Abstract

The present application discloses 17β hydroxy steroid dehydrogenase (17β HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17β HSD1 inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17β HSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17β HSD1 and 17β HSD3 that have a spiro-morpholine substituent at C20.

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