The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 27, 2021
Filed:
Jan. 30, 2018
Applicant:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;
Inventors:
Dansu Li, Warrington, PA (US);
Irit Snir-Alkalay, Mevasseret Zion, IL;
Joseph Vacca, Telford, PA (US);
Yinon Ben-Neriah, Mevasseret Zion, IL;
Avanthika Venkatachalam, Jerusalem, IL;
Assignee:
BioTheryX, Inc., Chappaqua, NY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 471/04 (2006.01); A61K 31/4439 (2006.01); A61K 31/506 (2006.01); A61K 31/4155 (2006.01); A61K 31/427 (2006.01); A61P 35/00 (2006.01); C07D 403/14 (2006.01); C07D 417/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); C07D 401/04 (2013.01); C07D 403/14 (2013.01); C07D 417/04 (2013.01);
Abstract
The present invention provides pyrazole derivatives of Formula (I), and in particular N1-(4-(5-(cyclopropylmethyl)-1-methyl-1H-pyrazol-4-yl) pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as casein kinase 1 (CK1) and/or interleukin 1 receptor associated kinase 1 (IRAKI) inhibitors for treating cancer, inflammatory and immune related disorders.