The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 27, 2021

Filed:

Mar. 19, 2020
Applicant:

Five Eleven Pharma Inc., Philadelphia, PA (US);

Inventors:

Zehui Wu, Philadelphia, PA (US);

Zhihao Zha, Philadelphia, PA (US);

Futao Liu, Philadelphia, PA (US);

Karl Ploessl, Wilmington, DE (US);

Seok Rye Choi, Aston, PA (US);

Hank F. Kung, Springfield, PA (US);

Assignee:

Five Eleven Pharma Inc., Philadelphia, PA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); A61K 51/04 (2006.01); A61B 6/03 (2006.01); C07B 59/00 (2006.01); C07D 221/06 (2006.01); C07D 213/64 (2006.01); C07D 405/04 (2006.01); C07C 217/80 (2006.01); C07D 471/04 (2006.01); C07C 323/37 (2006.01); C07D 277/66 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0455 (2013.01); A61B 6/037 (2013.01); A61K 51/04 (2013.01); A61K 51/0419 (2013.01); A61K 51/0431 (2013.01); A61K 51/0453 (2013.01); C07B 59/001 (2013.01); C07B 59/002 (2013.01); C07B 59/004 (2013.01); C07C 217/80 (2013.01); C07C 323/37 (2013.01); C07D 213/64 (2013.01); C07D 221/06 (2013.01); C07D 405/04 (2013.01); C07D 471/04 (2013.01); C07B 2200/05 (2013.01); C07D 277/66 (2013.01);
Abstract

The present invention relates to deuterated compounds according to Formula I-A, Formula II-A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents for evaluating Parkinson's Disease, Alzheimer Disease, and for determining specific serotonin reuptake inhibitor (SSRIi) activity for treatment of depression. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I-A, Formulae II-A, Formula II-D, or Formula III-A, or a pharmaceutically acceptable salt thereof.


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