The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 27, 2021
Filed:
Oct. 29, 2015
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Zheng-Yi Chen, Somerville, MA (US);
David R. Liu, Cambridge, MA (US);
Margie Li, Cambridge, MA (US);
David B. Thompson, Cambridge, MA (US);
John Zuris, Cambridge, MA (US);
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
Compositions are described for direct protein delivery into multiple cell types in the mammalian inner ear. The compositions are used to deliver protein(s) (such as gene editing factors) editing of genetic mutations associated with deafness or associated disorders thereof. The delivery of genome editing proteins for gene editing and correction of genetic mutations protect or restore hearing from genetic deafness. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.